MO154ASSESSMENT OF MILD COGNITIVE IMPAIRMENT IN PRE-DIALYSIS CHRONIC KIDNEY DISEASE AND ITS ASSOCIATION WITH INFLAMMATION AND CHANGES IN MRI: WHAT THE EYES DON´T SEE

Abstract Background and Aims Mild cognitive impairment (MCI) consists of a decline one or more domains, independent functional impairment. There are common pathophysiological factors between chronic kidney disease (CKD) MCI. The aim this study was to evaluate the association MCI in pre-dialysis CKD with inflammation markers alterations image exams (Nuclear Magnetic Resonance-MRI). Method Cross-sectional study, were evaluated non-dialysis patients categories 1 5 secondary care clinic, from 2013 2015. Inclusion Criteria: age ≥ 21 ≤ 65 years having signed informed consent form. Non-inclusion criteria: previous history stroke, degenerative infectious diseases CNS, presence delirium / psychotic disorders, mental retardation cranioencephalic trauma, visual auditory disorders that prevented tests, HIV AIDS, contraindication intolerance MRI. project approved by Research Ethics Committee. assessed using Montreal Cognitive Assessment (MoCA) estimated glomerular filtration rate (eGFR), CKDEPI formula. Socio-demographic clinical data collected medical records. Laboratory maximum 3 months after MoCA evaluation, as well measurement IL4, IL6, IL17, TNF alpha hs-CRP. brain MRI scans performed Siemens Avanto high-field device (1.5 Tesla), without use paramagnetic contrast. Fazekas scales used quantify white matter lesions, MTA scale hippocampal involvement, ACG for global cortical atrophy. Statistical analysis descriptive performed, followed comparison abnormal vs normal among all variables relevant tests; eGFR also correlated variables. Finally, we linear regression dependent variable, adjusting confounding Results 111 invited, 80 included neuropsychological assessment 56 stages study. mean 56.3 ± 8.3 years, 51.8% had an altered MoCA. Comparing those MoCA, observed there fewer schooling (p = 0.04), greater diuretics 0.04) AAS 0.002); addition higher levels IL6 0.02) IL17 0.05) no correlation eGFR. (R-0.201, p 0.04). (IL4 (R- -0.467, 0.005; -0.652, <0.001); -0.554, 0.001), -0.684, <0,001). findings In model, predictors lower values (CI -0.031 -0.002, 0.002; CI-0.012 -0.001, 0.002). Conclusion prevalence changes population 51.8%, inflammation, negatively IL6. inflammatory variables, not predictor values, while were.